ABCG 2 and PKD 2 polymorphisms correlate with gout-related metabolic indices in Chinese Han and Tibetan populations

Gout is a complex inflammation disease resulting from an increase in serum uric acid (SUA), which is one of the most common forms of inflammatory arthritis worldwide. Identification of the genetic factors of gout could be paramount contribution to early prevention of gout. Recent evidence suggests that heredity and metabolic syndrome contribute to gout development. ATP-binding cassette, sub-family G (ABCG2) and PKD2 may play a role in gout progression in Chinese and Han populations. A total of 455 patients (139 Han, 316 Tibetan) with gout and 627 healthy control subjects (309 Han, 318 Tibetan) were recruited for a case-control association study. Analysis of variance was used to evaluate the impact of polymorphism on gout based on metabolism indicators. Polymorphisms of the ABCG2 and PKD2 genes affected multiple risk factors for gout progression. Significant differences in alkaline phosphatase (AKP), high-density lipoproteins (HDL-C) and total bilirubin (TBIL) levels were detected between different genotypic groups with ABCG2 polymorphisms rs4693924, rs2622621, rs17731799 and rs3114020. In addition, significant differences in AKP, HDL-C and glutamic oxalacetic transaminase (AST) levels were detected between different genotypic groups with the PKD2 polymorphisms rs2728104, rs2728099 and rs2728121 in Chinese Han and Tibetan populations. Our results provided significant evidence for the potential relationships among ABCG2, PKD2 polymorphisms correlate with gout related metabolic indices in Chinese Han and Tibetan populations.