Polymorphisms in the Fat Mass and Obesity Associated ( FTO ) and Transcription factor 7-like 2 ( TCF 7 L 2 ) genes in Euro-Brazilian individuals with type 2 diabetes

Type 2 diabetes (T2D) is a condition that causes a substantial public health burden worldwide. In recent years, several genetic risk factors for diabetes have been identified. To examine the association of polymorphisms rs8050136 and rs9939609 in the FTO (Fat Mass and Obesity Associated) gene, and rs12255372 and rs7903146 in the TCF7L2 (Transcription factor 7-like 2) gene in a sample of Euro-Brazilian individuals with and without T2D. The genotype and allele frequencies for the studied polymorphisms did not demonstrate significant difference (P > 0.05) between the groups. In healthy individuals, the A-allele frequencies (95%CI) for FTO polymorphisms rs8050136 and rs9939609 were 39% (34%–44%) and 38% (34%–43%), respectively, while the T-allele frequencies for TCF7L2 polymorphisms rs12255372 and rs7903146 were 31% (26%– 35%) and 32% (28%–37%), respectively.