Effect of rosuvastatin on inflammatory factor , oxidative stress and cardiac function in patients with chronic heart failure

Chronic heart failure was terminal stage clinical syndrome that all kinds of cardiovascular disease developed to the most serious stage, which ventricular blood ejection and filling function was severely decreased, threatened badly patients life[1-3]. The related research revealed that inflammatory factors and oxidative stress could promote reconstruction of cardiac muscle, which was key factor that fastened heart failure and aggravated damage of cardiac function[4-6]. As a kind of common statins drug, rosuvastatin was widely applied to clinical treatment of cardiovascular disease, not only could good lipid-lowering function, but have anti-inflammatory and anti-oxidant function[7]. This research used rosuvastatin to treat patients with chronic heart failure and observed effect on inflammatory factor, oxidative stress and cardiac function, reported as following.