Jian Zheng Immunity in Humanized Mice Regulatory T Cells Inhibit GVHD and Preserve General + Human CD 8

may prevent the need for long-term general immunosuppression in BMT recipients. regs T hi humans, CD8 mechanism that involved CTLA-4, and, indeed, induced long-term tolerance. If these results can be translated to general immune responses intact. These cells decreased organ-specific chemokine and cytokine secretion through a reduced GVHD in an allospecific manner while leaving graft versus tumor and regs T hi generated CD8 − these ex vivo ) into a humanized model of GVHD. They found that regs regulatory T cells (T hi The authors transplant CD8 report a way to specifically inhibit GVHD in a humanized mouse model. et al. controlled by general immunosuppression, which has its own waterfall of negative side effects. Now, Zheng as ''nonself'' and attack. This side effect of BMT is called graft-versus-host disease (GVHD) and is −− treated the patient being −− to the recipient. Thus, immune cells that develop from the transplant recognize the new host they are antigenically foreign −− and nonmalignant diseases of the blood. Most bone marrow transplants are allogeneic unwanted side effects. One such therapy is bone marrow transplantation (BMT), which is used to treat both malignant Sometimes the treatment is worse than the disease. Therapies for critical illnesses frequently have severe Transplanting Hope