BRI 2 regulates β-amyloid degradation by increasing levels of secreted insulin degrading enzyme ( IDE )

Background: The British Precursor Protein (BRI2) influences Amyloid Precursor Protein metabolism. Results: BRI2 lowers β-amyloid peptide levels by increasing levels of secreted insulin degrading enzyme (IDE) in both cells and mice. Conclusion: BRI2 as a receptor protein regulates IDE levels and in turn promotes βamyloid degradation. Significance: Targeting the regulation of IDE may lead to new approaches to therapeutically address sporadic Alzheimer’s disease.