Human Papilloma Virus as Risk Factor for Non-melanoma Skin Cancer in Khartoum State-Sudan

This descriptive retrospective cross sectional study was carried out in Khartoum state, during the period from March to October 2015, to detect the association between human papilloma virus (HPV) infection and non-melanoma skin cancers using immunohistochemistry. 40 formalin fixed paraffin embedded blocks were collected from patients previously diagnosed as skin cancers, 20 samples were squamous cell carcinoma (SSC) and the remaining 20 samples were basal cell carcinoma (BCC). From each block only one section with 3μm in diameter were cut, to detect HPV using modified indirect immunohistochemical method (Thermo manufacture).The patient data were collected from patient file`s. Data was analyzed using SPSS computer program, frequencies, mean, chi square test were calculated. Among study group 26(65%) were males and 14(35%) were females, their age ranged between 20-90 year with mean age 36year. in SCC15 patients were more than 60 year and remaining 5 were less 1 Corresponding author: mohamedsiddig88@gmail.com Mohammed Siddig Abdelaziz, Manhal Osman Ahmed ElbarakaHuman Papilloma Virus as Risk Factor for Non-melanoma Skin Cancer in Khartoum StateSudan EUROPEAN ACADEMIC RESEARCH Vol. III, Issue 12 / March 2016 13068 than 60 year, while in BCC 10 patients were more than 60 year and other10 were less than 60 year. HPV were positive in 14 (35%) case,11 of them were SCC and the remaining 3(7.5%) were BCC, while negative in 26 (65%) case,17 (65%) of them were BCC and the remaining 9(22.5%) were SCC, with a significant association between HPV infection and type of skin cancer (P.value 0.008). The study concludes there is a significant association between HPV infection and type of skin cancers and no relation between age and sex with type of skin cancer.