Platelet-Derived Growth Factor / Vascular Endothelial Growth Factor Receptor Inactivation by Sunitinib Results in Tsc 1 / Tsc 2-Dependent Inhibition of TORC 1

Tram Anh Tran, Lisa Kinch, Samuel Peña-Llopis, Lutz Kockel, Nick Grishin, Huaqi Jiang, James Brugarolas Department of Developmental Biology, Department of Internal Medicine, Oncology Division, Simmons Comprehensive Cancer Center, and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, USA; Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA