In vitro antifungal activity of Cinnamum Burmannii and Cuminum Cyminum Essential Oils against two nosocomial strains of Aspergillus Fumigatus

Molds of the genus Aspergillus are among the ubiquitous fungi environment. Aspergillus fumigatus is one of the most dangerous nosocomials fungal pathogens especially in immunocompromised. In order to verify the medicinal virtues granted to some essential oils (EOs) which have a broad spectrum of applications (pharmaceutical and medicinal: bactericides, fungicides, antiparasitics), the objective of this study was to evaluate the antifungal activity of the EOs of two aromatic plants: Cuminum cyminum and Cinnamomum verum, on the mycelial growth of Aspergillus fumigatus. In this study, we isolated two strains of Aspergillus fumigatus (ASP37 and ASP42) from a pulmonary aspergillosis. The in vitro antifungal effects of the EOs tested were determined using the disk diffusion technique in the agar medium, and the microdilution method. The inhibitory effects of these oils indicated that the isolates of Aspergillus fumigatus tested were sensitive to both essential oils. The ASP37 was completely inhibited by both oils, while the ASP42 was inhibited by Cuminum cyminum and Cinnamomum verum with percentage inhibitions of 53% and 82%respectively. The essential oils of Cuminum cyminum and Cinnamomum verum can be used as a bio-antifungal against Aspergillus fumigatus responsible of chronic pulmonary aspergillosis.