Drug Disposition in Diseases Altering CYP450-Mediated Metabolism

Submit Manuscript | http://medcraveonline.com Abbreviations: AhR: Aryl Hydrocarbon Receptor; Arnt: Nuclear Translocator; CLP: Cecal Ligation and Puncture; CVB3: Coxsackievirus B3; CRP: C-Reactive Protein; CYP-450: Cytochrome P-450; ECOD: Ethoxycoumarin O-Deethylase; GH: Growth Hormone; IMND: Imipramine N-Demethylase; iNOS: inducible Nitric Oxide Synthetase; icv: intracerebroventricularly; IFN-γ: Interferon γ; IL: Interleukin; KC: Kupffer Cells; L-NAME: Nitro L-Arginine Methyl Ester; LPS: Lipopolysaccharides; NF-KB: Nuclear Factor-Kappa B; NO: Nitric Oxide; TLR: Toll Like Receptor; TNF-α: Tumor Necrosis Factor α; WT: Wild Type