Cardiac and Skeletal Muscles Show Molecularly Distinct Responses to Cancer 1 Cachexia 2 3

Cardiac and Skeletal Muscles Show Molecularly Distinct Responses to Cancer 1 Cachexia 2 3 Angie M.Y. Shum, David C.Y Fung, Susan M. Corley, Max C. McGill, Nicholas 4 Bentley, Timothy C. Tan, Marc R. Wilkins and Patsie Polly* 5 6 Inflammation and Infection Research Centre and Department of Pathology, New South 7 Wales Systems Biology Initiative, School of Biotechnology and Biomolecular Sciences, 8 Faculty of Science, UNSW Australia, NSW 2052, Australia. Mitochondrial Bioenergetics 9 Group, Department of Pharmacology, School of Medical Sciences, Faculty of Medicine, 10 UNSW Australia, NSW 2052, Australia. Blacktown Clinical School and Blacktown 11 Hospital, 18 Blacktown Road, Blacktown, NSW 2148, Australia. Cardiac Ultrasound 12 Laboratory, Massachusetts General Hospital, MA02114, USA. 13 14 15 16 †First co-authors 17 18 *Corresponding author: 19 A/Prof Patsie Polly 20 School of Medical Sciences, 21 Faculty of Medicine, 22 Rm 420 Wallace Wurth EAST Building, 23 UNSW Australia, 24 High Street, Kensington, 25 NSW 2052, AUSTRALIA 26 27 Email: patsie.polly@unsw.edu.au 28 Telephone: +612-9385-2924 29 Fax: +612-9385-1389 30 31 Running title: Different Molecular Responses to Cancer Cachexia in Muscle 32 33 Articles in PresS. Physiol Genomics (September 22, 2015). doi:10.1152/physiolgenomics.00128.2014