Met polymorphism is associated with post-traumatic stress disorder and functional outcome following mild traumatic brain injury

Mild traumatic brain injury (mTBI) results in variable clinical trajectories and outcomes. The source of variability remains unclear, but may involve genetic variations, such as single nucleotide polymorphisms (SNPs). A SNP in catechol-o-methyltransferase (COMT) is suggested to influence Corresponding author at: Department of Neurological Surgery, University of California, San Francisco, 1001 Potrero Avenue, Building 1, Room 101, San Francisco, CA 94110, USA. Fax: +1 (415) 206 3948. manleyg@neurosurg.ucsf.edu. 1Authors contributed equally to the manuscript. 2The TRACK-TBI Investigators are listed in the Appendix in alphabetical order by last name Registry: ClinicalTrials.gov Identifier NCT01565551. Conflict of interest No competing financial interests exist. Disclosure statement The authors have no competing interests to disclose. HHS Public Access Author manuscript J Clin Neurosci. Author manuscript; available in PMC 2018 January 01. Published in final edited form as: J Clin Neurosci. 2017 January ; 35: 109–116. doi:10.1016/j.jocn.2016.09.017. A uhor M anscript