Title 1 Distinct genetic architectures for syndromic and nonsyndromic congenital 2 heart defects identified by exome sequencing 3

Authors 4 Alejandro Sifrim, Marc-Phillip Hitz, Anna Wilsdon, Jeroen Breckpot, Saeed H. Al 5 Turki, Bernard Thienpont, Jeremy McRae, Tomas W Fitzgerald, Tarjinder Singh, 6 Ganesh Jawahar Swaminathan, Elena Prigmore, Diana Rajan, Hashim Abdul-Khaliq, 7 Siddharth Banka, Ulrike M. M. Bauer, Jamie Bentham, Felix Berger, Shoumo 8 Bhattacharya, Frances Bu'Lock, Natalie Canham, Irina-Gabriela Colgiu, Catherine 9 Cosgrove, Helen Cox, Ingo Daehnert, Allan Daly, John Danesh, Alan Fryer, Marc 10 Gewillig, Emma Hobson, Kirstin Hoff, Tessa Homfray, The INTERVAL Study, Anne11 Karin Kahlert, Ami Ketley, Hans-Heiner Kramer, Katherine Lachlan, Anne Katrin 12 Lampe, Jacoba J. Louw, Ashok Kumar Manickara, Dorin Manase, Karen P. McCarthy, 13 Kay Metcalfe, Carmel Moore, Ruth Newbury-Ecob, Seham Osman Omer, Willem H. 14 Ouwehand, Soo-Mi Park, Michael J. Parker, Thomas Pickardt, Martin O. Pollard, 15 Leema Robert, David J. Roberts, Jennifer Sambrook, Kerry Setchfield, Brigitte 16 Stiller, Chris Thornborough, Okan Toka, Hugh Watkins, Denise Williams, Michael 17 Wright, Seema Mital, Piers E. F. Daubeney, Bernard Keavney, Judith Goodship, The 18 UK10K Consortium, Riyadh Mahdi Abu-Sulaiman, Sabine Klaassen, Caroline F. 19 Wright, Helen V. Firth, Jeffrey C. Barrett, Koenraad Devriendt, David R. FitzPatrick, J. 20 David Brook, The Deciphering Developmental Disorders Study, Matthew Hurles 21 22