Cystic renal cell carcinoma: a surveillance, epidemiology, and end results database analysis

Purpose: To explore the risk factors affecting the prognosis of patients with cystic renal cell carcinoma (CRCC). Methods: We identified 1,135 patients diagnosed with CRCC from 1973 to 2015 in the Surveillance, Epidemiology, and End Results (SEER) database and the incidence was calculated. Kaplan-Meier analysis was used to compare the cancer-specific and overall survival rates. COX multivariate regression analysis was used to analyze the relationships between the influencing factors. The factors analyzed included marital status, age at diagnosis, year of diagnosis, sex, race, tumor grade, laterality, TNM stage, AJCC stage, SEER stage, surgery on primary tumor and regional lymph node dissection. Results: According to the data analysis, the 5-year overall survival rate of CRCC patients was 87.3%, and the 5-year cancer-specific survival rate was 94.7%. COX multivariate regression analysis showed that marital status, AJCC stage and surgery on primary tumors had statistical significance in predicting cancer-specific survival, while marital status and surgery on primary tumors had statistical significance in predicting overall survival. Conclusion: Although CRCC has the characteristics of low stage, low grade, low malignancy and good prognosis, early diagnosis and treatment are necessary to improve the prognosis of CRCC. Marital status, AJCC stage and surgery on primary tumor can be used as independent prognostic factors for CRCC and guiding clinical practice.