Hypolipidemic effects of Lysinibacillus sphaericus fermented tomato and carrot juices in high-fat diet-fed albino Wistar rats

We have conducted the present study to evaluate the effect of probioticated tomato juice (PTJ), probioticated carrot juice (PCJ), and their mixed juices (PCT) containing Lysinibacillus sphaericus on high-fat diet (HFD)-fed albino Wistar rats. Eight groups consisting of 6 rats each were designed in the experiments and orally administered the above probioticated juices (at 1–2 mL per rat) to HFD-fed rats for 28 days. This included a group maintained on normal control diet (NCD), HFD, and an experimental control group maintained using lovastatin (at 5 mg/kg body weight). After feeding the rats, the lipid profile of the blood serum was studied in all the eight groups. HFD-fed rats showed elevated lipid profile levels as compared to NCD-fed rats. Probioticated juices reversed the elevated lipid profile levels to near normal in HFD-fed rats. This hypolipidemic effect was more significant in PCJ-fed (2 mL/rat) groups than the other groups. On treatment with the PTJ, PCJ and PCT showed the lowering of body weights when compared to HFD group.