Adfs, a Novel Tumor-promoting Cell Type Adipocyte-derived Fibroblasts Promote Tumor Progression and Contribute to the Desmoplastic Reaction in Running Title: Adfs, a Novel Tumor-promoting Cell Type

1 Adipocyte-Derived Fibroblasts promote tumor progression and contribute to the desmoplastic reaction in 1 breast cancer. 2 Ludivine Bochet , Camille Lehuédé, Stéphanie Dauvillier , Yuan Yuan Wang , Béatrice Dirat , 3 Victor Laurent , Cédric Dray , Romain Guiet , Isabelle Maridonneau-Parini , Sophie Le Gonidec , 4 Bettina Couderc, Ghislaine Escourrou , Philippe Valet 1,3 and Catherine Muller 1,2 * 5 6 1 Université de Toulouse, UPS, F-31077 Toulouse, France. 7 2 CNRS ; Institut de Pharmacologie et de Biologie Structurale F-31077 Toulouse, France. 8 3 Institut National de la Santé et de la Recherche Médicale, INSERM U1048, F-31432 Toulouse, France. 9 4 Institut Claudius Regaud, EA3035, F-31052 Toulouse, France. 10 5 Service d’Anatomo-Pathologie, Hôpital de Rangueil, 31403 Toulouse, France. 11 # The two first authors contributed equally to this work 12 13 Running title: ADFs, a novel tumor-promoting cell type 14