Cancer Therapy : Preclinical Monoclonal Antibody against Cell Surface GRP 78 as a Novel Agent in Suppressing PI 3 K / AKT Signaling , Tumor Growth , and Metastasis

Ren He Liu,Xiuqing Li,Wenming Gao,Yue Zhou, Shiuan Wey, Satyajit Sujit Kumar Mitra,Valery Krasnoperov, Dezheng Dong,Shuanglong Liu,Dan Li,Genyuan Zhu,Stan G. Louie,Peter S. Conti,Zibo Li,Amy S. Lee,Parkash S. Gill

semanticscholar（2013）

引用 0|浏览7

暂无评分

摘要

Purpose: The ER chaperone GRP78 translocates to the surface of tumor cells and promotes survival, metastasis, and resistance to therapy. An oncogenic function of cell surface GRP78 has been attributed to the activation of the phosphoinositide 3-kinase (PI3K) pathway. We intend to use a novel antiGRP78 monoclonal antibody (MAb159) to attenuate PI3K signaling and inhibit tumor growth and

查看译文

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要