Neurobiology of Disease TRPA 1 Contributes to Cold Hypersensitivity

Donato del Camino,1 Sarah Murphy,1 Melissa Heiry,1 Lee B. Barrett,4 Taryn J. Earley,3 Colby A. Cook,1 Matt J. Petrus,2 Michael Zhao,1 Marc D’Amours,1 Nate Deering,1 Gary J. Brenner,5 Michael Costigan,4 Neil J. Hayward,1 Jayhong A. Chong,1 Christopher M. Fanger,1 Clifford J. Woolf,4 Ardem Patapoutian,2,3 and Magdalene M. Moran1 1Hydra Biosciences, Inc., Cambridge, Massachusetts 02139, 2Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, 3Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, 4F. M. Kirby Neurobiology Center, Children’s Hospital Boston, and Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, and 5Neuronal Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129