Methylation-associated DOK 1 and DOK 2 down-regulation : potential biomarkers for predicting adverse prognosis in acute myeloid leukemia † Running title : DOK 1 / 2 expression and methylation in AML

#These authors contributed equally to this work. 1Laboratory Center, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, Jiangsu, People’s Republic of China 2The Key Lab of Precision Diagnosis and Treatment of Zhenjiang City, Zhenjiang, Jiangsu, People’s Republic of China 3Department of Hematology, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, Jiangsu, People’s Republic of China 4Department of Hematology, The Third People’s Hospital of KunShan City, Kunshan, Jiangsu, People’s Republic of China 5School of medicine, Jiangsu University, Zhenjiang, Jiangsu, People’s Republic of China