Abstracts of the 9th HIV Persistence During Therapy Workshop

Thomas A. Rasmussen,Laskhmi Rajdev,Ajantha Rhodes,Ashanti Dantanarayana, Surekha Tennakoon, Socheata Chea, Danielle Rigau,Shelly Lensing,Rachel Rutishauser,Sonia Bakkour, Michael Busch,Dirk P. Dittmer, Steven Deeks,Christine Durand, J. Cyktor, R. Gandhi, R. Bosch,H. Mar, G. Laird, B. Macatangay, J. Eron, R. Siliciano, D. Mcmahon, J. Mellors, L. Giron, E. Papasavvas, L. Azzoni, K. Mounzer, J. Kostman, I. Sanne, C. Firnhaber, Q. Liu, L. Montaner

Journal of Virus Eradication（2019）

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摘要

Background: The main barrier to an HIV cure is the latent HIV reservoir. Long-lived HIV latently-infected cells remain invisible to the host immune system and persist during antiretroviral therapy. In this study, we characterized latently-infected cells by implementing combined transcriptomic and proteomic profiling to identify unique expression signatures and reliable biomarkers that can be exploited to target and eliminate the latent reservoir.

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