GW26-e3532 miR-433 Controls Cardiac Fibrosis

RESULTS After one week of right ventricular pacing, cardiac ultrasound examination confirmed the left ventricular end diastolic diameter enlargement, reduction of left ventricular ejection fraction, increased serum BNP and MMP-9, and decreased TIMP-1. Pathology of HE staining showed myocardial structural derangement and interstitial inflammatory cell infiltration. Electron microscopy revealed mitochondrial swelling, dissolution, or even lysis and destruction, fuzzy Z line and unclear intercalated discs. Three weeks later, the heart color, serum BNP, MMP-9, TIMP-1, EF, FS in the rabbits recovered to former levels.