Human RORgtCD34 Cells Are Lineage-Specified Progenitors of Group 3 RORgt Innate Lymphoid Cells

Elisa Montaldo,1,2 Luiz Gustavo Teixeira-Alves,3 Timor Glatzer,3 Pawel Durek,4 Ulrik Stervbo,4 Wiebke Hamann,3 Marina Babic,3,5 Daniela Paclik,3 Katharina Stölzel,6 Jörn Gröne,7 Laura Lozza,8 Kerstin Juelke,3,9 Nadine Matzmohr,10 Fabrizio Loiacono,11 Francesca Petronelli,11 Nicholas David Huntington,12 Lorenzo Moretta,11 Maria Cristina Mingari,1,2 and Chiara Romagnani3,* 1Department of Experimental Medicine, University of Genova, Via LB Alberti 2, 16132 Genova, Italy 2UOC Immunologia, IRCCS-AOU-San Martino-IST, L.go R. Benzi 10, 16132 Genova, Italy 3Innate Immunity, Deutsches Rheuma Forschungszentrum (DRFZ) Berlin, Leibniz-Gemeinschaft, Charitéplatz 1, 10117 Berlin, Germany 4Cell Biology, Deutsches Rheuma Forschungszentrum (DRFZ) Berlin, Leibniz-Gemeinschaft, Charitéplatz 1, 10117 Berlin, Germany 5Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, B. Branchetta 20a, 51000 Rijeka, Croatia 6HNO-Klinik-Charité-Universitätsmedizin, Charitéplatz 1, 10117 Berlin, Germany 7Klinik für Allgemein-, Gefäßund Thoraxchirurgie Charité-Universitätsmedizin, Hindenburgdamm 30, 12203 Berlin, Germany 8Department of Immunology, Max Planck Institute for Infection Biology, Charitéplatz 1, 10117 Berlin, Germany 9Immune System, Berlin-Brandenburg Center for Regenerative Therapies (BCRT) Charité-Universitätsmedizin, Augustenburger Platz 1, 13353 Berlin, Germany 10Immune Regeneration and Aging, Berlin-Brandenburg Center for Regenerative Therapies (BCRT) Charité-Universitätsmedizin, Augustenburger Platz 1, 13353 Berlin, Germany 11Giannina Gaslini Institute, Via G. Gaslini 5, 16147 Genova, Italy 12Department of Medical Biology, The Walter and Eliza Hall Institute of Medical Research, The University of Melbourne, 1G Royal Parade, Parkville, VIC 3052, Australia *Correspondence: romagnani@drfz.de http://dx.doi.org/10.1016/j.immuni.2014.11.010