1 Saccharomyces cerevisiae Dmc 1 and Rad 51 preferentially function with Tid 1 and Rad 54 , respectively , to promote DNA strand invasion during genetic recombination

Background: DNA strand exchange proteins, Dmc1 and Rad51, and translocases, Tid1 and Rad54, function in DNA break repair during meiosis. Results: We biochemically demonstrate that Dmc1 and Rad51 are specifically stimulated by Tid1 and Rad54, respectively. Conclusions: Dmc1-Tid1 and Rad51-Rad54 represent functional pairs for DNA pairing and joint molecule formation. Significance: The separate and independent functioning of these proteins offers insight into DNA pairing in meiosis.