Novel Pentameric ThiopheneDerivatives for in Vitro and in Vivo Optical Imagingof aPlethora of ProteinAggregates inCerebral Amyloidoses

Andreas Åslund, Christina J. Sigurdson, Therése Klingstedt, Stefan Grathwohl, Tristan Bolmont, Dara L. Dickstein , Eirik Glimsdal , Stefan Prokop, Mikael Lindgren , Peter Konradsson, David M. Holtzman, Patrick R. Hof , Frank L. Heppner, Samuel Gandy , Mathias Jucker, Adriano Aguzzi, Per Hammarström, and K. Peter R. Nilsson* Department of Chemistry, IFM, Linköping University, SE-581 83 Linköping, Sweden, Institute of Neuropathology, Department of Pathology, Universitätsspital Zürich, Schmelzbergstrasse 12, CH-8091 Zürich, Switzerland, Department of Cellular Neurology, Hertie-Institute for Clinical Brain Research, University of Tuebingen, D-72076 Tuebingen, Germany, Department of Neuroscience, Mount Sinai School of Medicine, New York, New York 10029, Alzheimer’s Disease Research Center, Mount Sinai School of Medicine, New York, New York 10029, Department of Physics, Norwegian University of Science and Technology, N-7491 Trondheim, Norway, Department of Neuropathology, Charité-Universitätsmedizin Berlin, D-13353 Berlin, Germany, Department of Neurology, Alzheimer’s Disease Research Center, Washington University, St. Louis, Missouri 63110, and Departments of Neurology and Psychiatry, Mount Sinai School of Medicine, New York, New York 10029