Prinzmetal ’ s angina with multivessel spasm successfully treated by using two different types of calcium channel blockers

Contact address: Ionut Donoiu Department of Cardiology, University of Medicine and Pharmacy, 2nd Petru Rares Street, 200349, Craiova, Romania. E-mail address: ionut.donoiu@umfcv.ro 1 Department of Cardiology, County Clinical Emergency Hospital, Craiova, Romania 2 Department of Cardiology, University of Medicine and Pharmacy, Craiova, Romania 3 Department of Cardiology, „Filantropia” Hospital, Craiova, Romania Abstract: Prinzmetal’s angina is characterized by recurrent episodes of chest pain which occur during rest or sleep, associated with transient elevation of the ST segment on the electrocardiogram. The underlying mechanism is focal or diffuse coronary artery spasm that can affect one or multiple coronary artery sites simultaneously or consecutively. We report the case of a 53-year-old woman with persistent angina which presented with multivessel spasm recorded during coronary angiography without provocation test. The symptomatology of the patient was effectively relieved by combining two calcium channel blockers with a selective inhibitor of phosphodiesterase–3 and a long-lasting nitrate.