Distinct Protein Degradation Profiles Are Induced by Different Disuse Models of 1 Skeletal Muscle Atrophy 2 Running Title: Distinct Protein Degradation Pathways in Muscle Atrophy

Distinct Protein Degradation Profiles Are Induced by Different Disuse Models of 1 Skeletal Muscle Atrophy 2 Running Title: Distinct Protein Degradation Pathways in Muscle Atrophy 3 4 Peter Bialek, Carl Morris, Jascha Parkington, Michael St.Andre, Jane Owens, Paul 5 Yaworsky, Howard Seeherman, Scott A. Jelinsky 6 7 Tissue Repair, Pfizer Research, 200 Cambridge Park Drive, Cambridge, MA 02140 USA 8 9 * To whom correspondence should be addressed at: 10 Scott Jelinsky, Ph.D. 11 Pfizer Research 12 200 CambridgePark Drive 13 Cambridge, MA 02140 14 Ph. 617-665-5366 15 Fax 617-665-5320 16 Email: Scott.Jelinsky@pfizer.com 17 18 Articles in PresS. Physiol Genomics (July 26, 2011). doi:10.1152/physiolgenomics.00247.2010