The Prp 43 p helicase is stimulated by the G-patch protein Pfa 1 p during yeast ribosome biogenesis

Thank you for submitting your manuscript to the EMBO journal. Your manuscript has now been seen by three referees and their comments to the authors are provided below. While there is an interest in the analysis it is also clear that further work is needed in order to consider publication in the EMBO journal. The referees raise a number of different issues with the analysis that has to be resolved. One issue raised is that the function and significance of Pfa1p needs to be further clarified and that further insight into the contributions of Gno1p and Ltv1p is needed. Should you be able to extend the analysis and address the concerns raised in full, we would consider a revised manuscript. I would like to add that it is EMBO Journal policy to allow a single round of revision only and it is therefore essential that you completely answer the points raised if you wish the manuscript ultimately to be accepted.