Differences in pharmacological property between combined therapy of the vasopressin V2-receptor antagonist tolvaptan plus furosemide and monotherapy of furosemide in patients with hospitalized heart failure

Koji Takagi,Naoki Sato,Shiro Ishihara, Hayano Iha,Noriyuki Kobayashi,Yusuke Ito,Tsuyoshi Nohara,Satoru Ohkuma, Tatsuya Mitsuishi, Atsushi Ishizuka,Shota Shigihara, Michiko Sone, Kenji Nakama,Hideo Tokuyama,Toshiya Omote,Arifumi Kikuchi,Shunichi Nakamura,Eisei Yamamoto,Masahiro Ishikawa,Kenichi Amitani,Naoto Takahashi,Yuji Maruyama,Hajime Imura,Wataru Shimizu

Journal of Cardiology（2020）

引用 3|浏览17

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摘要

•Tolvaptan is a diuretic agent with electrolyte-free water diuretic properties.•Total body water is composed of intracellular water (ICW) and extracellular water (ECW).•Combined therapy with tolvaptan and furosemide removed excess ICW and ECW equally.•Furosemide alone primarily removed ECW, including intravascular water.

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关键词

Heart failure,Furosemide,Tolvaptan,Fluid compartments

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