Sphingosine-1-Phosphate Lyase (SGPL1) Deficiency Is Associated with Mitochondrial Dysfunction

Avinaash Maharaj,Teisha Bradshaw,Jack Williams,Tulay Guran,Debora Braslavsky,Britta Bruegger,Lou Metherell,Rathi Prasad

The Journal of Steroid Biochemistry and Molecular Biology（2018）

引用 19|浏览12

暂无评分

摘要

•Sphingosine-1-phosphate (S1P) lyase deficiency leads to accumulation of upstream sphingolipid species.•Acute steroidogenesis is impaired in S1P lyase deficient patient dermal fibroblasts.•S1P lyase deficiency affects mitochondrial morphology and dynamics.•Parameters of oxidative phosphorylation are altered in S1P lyase deficiency.

查看译文

关键词

Sphingolipid metabolism,Mitochondrial dynamics,Steroidogenic capacity,Oxidative phosphorylation,Sphingosine-1-phosphate lyase

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要