Adaptive weighted sum tests via LASSO method in multi-locus family-based association analysis

Rui Liu,Min Yuan,Huang Xu, Pinzhong Chen,Xu Steven Xu,Yaning Yang

Computational Biology and Chemistry（2020）

引用 4|浏览18

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摘要

•Family-based association test (FBAT) are robust against the population stratification.•Multi-SNP tests are more powerful than single-SNP methods as taking the covariance structure into consideration.•Rare variant analysis is crucial to finding genetic causes for some complex diseases.•Weighted sum statisitc using LASSO regression outperforms other tests in various GWAs designs.

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关键词

Family based design,Genetic association studies,Multi-locus,LASSO,Robust-efficient

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