Biomarkers for CTE diagnosis in retired NFL player using Machine learning

Multiple concussions have the potential to develop Chronic Traumatic Encephalopathy (CTE), a neurodegenerative disease that is currently diagnosed only in postmortem by tau protein deposition in the brain. Since repetitive head trauma alters brain morphology and metabolism, magnetic resonance imaging and spectroscopy could be suitable candidates for CTE diagnosis. Therefore, we propose machine learning-based approach to identify CTE-related biomarkers. The model achieves 80% prediction accuracy with AUC of 0.72 using creatine, macromolecules and brain volume as features for the machine learning model.