Transient receptor potential melastatin 2 contributes to neuroinflammation and negatively regulates cognitive outcomes in a pilocarpine-induced mouse model of epilepsy

•TRPM2 knockout reduced inflammatory responses in the hippocampus in a pilocarpine model of epilepsy.•TRPM2 knockout reduced the epilepsy-induced neurodegeneration and autophagy in the hippocampus.•TRPM2 ameliorated the cognitive impairment induced by the epilepsy.