A Meta-Analysis Andin Silicoanalysis Of Polymorphic Variants Conferring Breast Cancer Risk In The Indian Subcontinent

Background:Genetic association studies on breast cancer on the Indian subcontinent have yielded conflicting results, and the precise effect of these variants on breast cancer pathogenesis is not known.Methods:Genomic variants, as obtained from selected studies from the Indian subcontinent, were subjected to random-effects and fixed-effect meta-analysis. Functional annotation of the relevant variants was done through a tried and testedin silicopipeline.Results:We found rs4646903/CYP1A1, rs1799814/CYP1A1, rs61886492/GCPII, del2/GSTM1, rs4680/COMTand rs1801394/MTRRto be associated with breast cancer. The del2/GSTM1holds the association in premenopausal women.Conclusions:This is the first study of its kind from the Indian subcontinent analysing the extent of association of variants across populations followed by their functional annotation in the disease pathway.