Distance to white matter trajectories is associated with treatment response to internal capsule deep brain stimulation in treatment-refractory depression

Luka C Liebrand,Samuel J Natarajan,Matthan W A Caan,P Richard Schuurman,Pepijn van den Munckhof,Bart de Kwaasteniet,Judy Luigjes,Isidoor O Bergfeld,Damiaan Denys,Guido A van Wingen

NeuroImage: Clinical（2020）

引用 11|浏览24

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摘要

•Stimulation closer to tracts was associated with better outcome in DBS for depression.•Lead placement was consistent across (non)responders w.r.t. anatomical landmarks.•Tractography-guided surgery needed to ensure tracts lie within activated tissue.

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关键词

ACC,ALIC,ATR,CT,DBS,dMRI,HAM-D,MDD,NAc,OCD,OFC,PFC,slMFB,TRD,VAT,VTA

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