Combination of matrix solid phase dispersion and response surface evaluation for simultaneous detections of multiple bioactive constituents of traditional Chinese medicine formula: Using Baoyuan Capsule as an example

•Combined solid phase extraction, LC-QTrap-MS and response surface evaluation for quality of TCM preparation.•Matrix Solid Phase Dispersion was applied for quickly and efficiently extraction of TCM formula preparation.•Matrix Solid Phase Dispersion condition was optimized by response surface evaluation.•LC-QTrap-MS related accurate methods were developed to simultaneous analyze 13 bioactive constituents as bioactive markers in the BYC.