Clinical values of creatine kinase and its isoenzymes in children and adolescents with vasovagal syncope

Background and aim: Vasovagal syncope (WS) in children and adolescents is a common disorder. There may be an internal relationship between creatine kinase (CK) and its isoenzymes (CKMB) and syncope. The aim of this study was to evaluate the changes of CK and CKMB in children and adolescents with VVS. Methods and results: The VVS group included 218 patients (93 male and 125 female). The control group included 129 healthy children (78 male and 51 female). Serum CK and CKMB levels were estimated. We founded (1)Serum CK and CK-MB levels decreased in WS group than that in control group (P < 0.05). (2)The CK levels of female were significantly lower than those of male in VVS group (P < 0.05). (3)Serum level of CK-MB were in negative correlation with age, height, weight, BMI whereas in positively correlation with HR. (4)CK was effected by CK-MB (beta = 0.147, P = 0.037) while CK-MB was independently influenced by age (beta = -0.203, P = 0.002) and DBP (beta = 0.171, P = 0.011). (5)Both CK and CK-MB significantly influenced on VVS occurrence after adjusting for the effects of gender, age, height, weight, BMI and HR. Conclusion: The serum CK and CKMB levels decrease in children and adolescents with VVS. CK and CK-MB are the independent protective factors with VVS. (C) 2020 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.