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Hyperoxia Affects the Lung Tissue: A Porcine Histopathological and Metabolite Study Using Five Hours of Apneic Oxygenation

Sigríður Olga Magnúsdóttir,Raluca Georgiana Maltesen, Lise Haugaard Banch,Ulrik Thorngren Baandrup, Heidi Valbjørn,Trygve Andreassen,Tone Frost Bathen,Bodil Steen Rasmussen,Benedict Kjærgaard

Metabolism open（2019）

Cited 4|Views8
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Abstract
•No significant histopathological changes in lung tissue after five hours hyperoxia.•Five hours hyperoxia induces significant metabolite changes in lung tissue.•Hyperoxia affects cellular energy, Krebs cycle, and oxidant-antioxidant defense.
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Key words
Apneic oxygenation,Hyperoxia,Lung tissue,Histopathology,Porcine model,Metabolites
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