In Vivo Evidence For Radiation-Induced Enrichment Of Glioma Stem-Like Cells In A Proneural Mouse Model Of Glioblastoma

Quincey Laplant,Ken Pitter,Anne-Marie Bleau,Karim Helmy, Jillian Werbeck,Lindy Barrett,Fumiko Shimizu,Robert Benezra,Viviane Tabar,Eric Holland

Neuro-oncology（2012）

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摘要

Ionizing radiation (IR) represents the most effective therapy for glioblastoma. However, radiotherapy remains palliative due to inevitable tumor recurrence. The vast majority of recurrence occurs centrally within the field of irradiation, suggesting that subsets of glioma cells have intrinisic radio

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