Evolution Of Proteins Is Darwinian Reply To Koonin Et Al

I am grateful to Koonin et al. (1) for highlighting the question of whether positive Darwinian evolution occurs at the molecular level, or only neutral evolution (generally accepted). In a series of papers, I have displayed evidence for positive Darwinian evolution of proteins, using a new hydropathic method based on statistical physics (self-organized criticality) (2) and (synchronizable) network theory (3, 4). While the main structural features of proteins have been formed over long times, the recent evolution of many proteins shows features evolving with function in a way not explained by conservation of the protein fold. A classic example is hen egg white, whose peptide backbone has remained … \n\n[↵][1]1Email: jcphillips8{at}comcast.net.\n\n [1]: #xref-corresp-1-1