Acylated Flavoneo-Glucuronides From The Aerial Parts Ofnepeta Curviflora

Nepeta curvifloraBoiss. (Syrian catnip) is native to the Middle East. This medicinal plant is commonly used against nervous disorders, rheumatic pains, and high blood pressure. Herbal infusions prepared from variousNepetaspp. are extensively consumed as functional food. However, limited information has been known about the phenolic constituents of Syrian catnip. In this study, two acylated flavone 7-O-glucuronides, apigenin 7-O-(2 ''-O-(2"'-(E-caffeoyl)-beta-glucuronopyranosyl)-beta-glucuronopyranoside) (1) and luteolin 7-O-(2 ''-O-(2"'-(E-caffeoyl)-beta-glucuronopyranosyl)-beta-glucuronopyranoside) (2), along with the known phenolic compounds rosmarinic acid, caffeic acid, apigenin, and apigenin 7-O-beta-glucopyranoside were isolated from the aerial parts ofN. curviflora. The characterizations of these compounds were based on high-resolution mass spectrometry, UV, and extensive use of multidimensional NMR spectroscopy. The new compounds (1and2) were identified in the unmodified state and as dimethylesters.