High catalytic efficiency from Er 3+ -doped CeO 2-x nanoprobes for in vivo acute oxidative damage and inflammation therapy.

Cerium oxide nanoparticles (NPs) due to their advanced catalytic performance have been widely used to treat oxidative damage. However, Ce(2)O(3)NPs have not been further investigated in the treatment of acute oxidative injuryin vivo. It is meaningful to improve the efficiency for treatment of acute oxidative injury with NPsin vivo. In this report, we designed Er3+-doped Ce2O3(Er/Ce2O3) NPs with a size of 7.9 nm, which were used to treat acute liver injury. Er/Ce(2)O(3)NPs realized high-efficiency catalysis of hydrogen peroxide (H2O2) at room temperature. An acute liver damage model was established through intraperitoneal injection of lipopolysaccharide (LPS) in C57 mice. By analyzing histopathological and biochemical indexes, Er/Ce(2)O(3)NPs showed a significant improvement in LPS-induced acute liver injury. Acute liver oxidative damage can be treated within 24 hours, which proved the high catalytic efficiency of Er/Ce(2)O(3)NPsin vivo. The activities of SOD, GPx and CTA increased and production of ROS decreased with Er/Ce2O3NP treatment in comparison with LPS-induced injury, indicating that the mechanism of Er/Ce(2)O(3)NPs in the treatment of acute oxidative damage of liver was mainlyviacatalysis of ROS products. Moreover, the protein expression levels of TNF-alpha, CD45 and IL-1 beta in liver decreased in the Er/Ce(2)O(3)NPs-treated group, which indicated that Er/Ce(2)O(3)NPs have the function of anti-inflammation property. Therefore, Er/Ce(2)O(3)NPs can be applied to treat and prevent diseases caused by acute oxidative damage.