Two Fatal Cases of Acute Liver Failure Due to HSV-1 Infection in COVID-19 Patients Following Immunomodulatory Therapies

Stefano Busani,Andrea Bedini,Emanuela Biagioni,Lucia Serio,Roberto Tonelli,Marianna Meschiari,Erica Franceschini,Giovanni Guaraldi,Andrea Cossarizza,Enrico Clini,Antonino Maiorana,William Gennari,Nicola De Maria,Mario Luppi,Cristina Mussini,Massimo Girardis

CLINICAL INFECTIOUS DISEASES（2021）

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摘要

We report two fatal cases of acute liver failure secondary to herpes simplex virus 1 infection in COVID-19 patients, following tocilizumab and corticosteroid therapy. Screening for and prompt recognition of herpes simplex virus 1 reactivation in these patients, undergoing immunomodulatory treatment, may have potentially relevant clinical consequences.

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