Comparison of the Lung Clearance Index in Preschool Children With Primary Ciliary Dyskinesia and Cystic Fibrosis

Jobst F Roehmel, Friederike J Doerfler,Cordula Koerner-Rettberg,Folke Brinkmann,Anne Schlegtendal,Martin Wetzke,Isa Rudolf,Simone Helms,Joerg Große-Onnebrink,Yin Yu, Thomas Nuesslein,Irena Wojsyk-Banaszak,Sebastian Becker,Olaf Eickmeier,Olaf Sommerburg,Heymut Omran,Mirjam Stahl,Marcus A Mall

Chest（2022）

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摘要

This study demonstrated early onset of lung disease in preschool children with PCD and indicated that lung disease severity in PCD may be similar to that in CF during preschool years. These data support a need for early diagnostic monitoring and therapy and suggest the LCI as a noninvasive diagnostic tool and as a potential end point in clinical trials testing early interventions in children with PCD.

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关键词

cystic fibrosis,lung clearance index,lung function test,multiple-breath washout,preschool children,primary ciliary dyskinesia

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