Tumor necrosis factor-α promotes Staphylococcus aureus-induced osteomyelitis through downregulating endothelial nitric oxide synthase

Xin Ma,Wenyang Xia,Yang Zong,Chaolai Jiang,Haojie Shan,Yiwei Lin,Fuli Yin,Nan Wang,Lihui Zhou,Gen Wen,Zubin Zhou

Journal of Microbiology, Immunology and Infection（2021）

引用 7|浏览15

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摘要

Our study thereby proposes a novel signalling cascade involving TNF-α/miR-129-5p/eNOS in the pathogenesis of osteomyelitis, which may also serve as therapeutic targets.

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关键词

Osteomyelitis,Tumor necrosis factor-α,Staphylococcus aureus,Endothelial nitric oxide synthase,Oxidative stress

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