Does sampling saliva increase detection of SARS-CoV-2 by RT-PCR? Comparing saliva with oro-nasopharyngeal swabs

•SARS-CoV-2 detection from saliva was more consistent during extended hospitalization and recovery.•Testing saliva samples before the end of isolation in individuals under treatment can be effective in spreading Covid-19.•Taking saliva samples along with the standard method before ending the isolation in individuals treated with hydroxychloroquine can be effective in minimizing contamination in the community by reducing the false negativity rate.