NR4As apply brakes on the B cell response
NATURE IMMUNOLOGY（2020）
摘要
To trigger an adequate humoral immune response while ensuring self-tolerance, B cell activation is tightly controlled. A new study indicates that an NR4A-enforced built-in brake fine-tunes the early phase of transcriptional reprogramming induced by BCR stimulation.
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关键词
Clonal selection,Follicular B cells,Humoral immunity,Biomedicine,general,Immunology,Infectious Diseases
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