Severity of Subjective Forgetfulness is Associated with High Dietary Intake of Copper in Japanese Senior Women: A Cross- Sectional Study

This study investigated the relationship between subjective forgetfulness and the dietary intake of various nutrients in middle-aged and senior women. A cross-sectional study of the first-visit records of 245 Japanese women aged 40 or over was performed. The severity of subjective forgetfulness was classified according to the Menopausal Health-Related Quality of Life Questionnaire: none and mild ("unforgetful") or moderate and severe ("forgetful"). Dietary consumption of nutrients was estimated using the brief-type self-administered diet history questionnaire. The associations between the severity of subjective forgetfulness and intake of 43 major nutrients were evaluated using multivariate logistic regression analysis separately performed for two age groups: middle-aged (40-54 years, N = 166) and senior (55 years or over, N = 79). No nutrients were found to be significantly associated with subjective forgetfulness in the middle-aged group. In senior women, a significant positive relationship between the intake of copper and forgetfulness was found (adjusted odds ratio per 10 mg/kJ increase in copper intake: 1.25; 95% confidence interval: 1.08-1.50). Thus, high copper intake is positively associated with the severity of forgetfulness in Japanese senior women. Reducing copper consumption could help improve this symptom in this population.