Adamts9-As2andcadm2expression And Association With The Prognosis In Esophageal Squamous Cell Carcinoma

Background:We investigated whetherADAMTS9-AS2andCADM2were related to esophageal squamous cell carcinoma (ESCC).Methodology:ESCC microarray datasets and reverse transcriptase qualitative PCR were used to analyzeADAMTS9-AS2andCADM2expression.Results:The GSE120356 and GSE33810 datasets identifiedADAMTS9-AS2andCADM2as the candidates andADAMTS9-AS2andCADM2expression was downregulated in ESCC.ADAMTS9-AS2andCADM2were positively correlated with ESCC.ADAMTS9-AS2andCADM2expression could discriminate ESCC from normal tissue. Five-year overall survival was shorter in underexpressedADAMTS9-AS2patients, andCADM2expression level was related to 5-year overall survival.ADAMTS9-AS2andCADM2expression were independent prognosis indicators in ESCC patients.Conclusion:Our findings shed new light on the clinical significance ofADAMTS9-AS2andCADM2in ESCC carcinogenesis.