MP55 07 PREDICTIVE AND PROGNOSTIC ROLE OF A SIMPLE IMMUNO PHENOTYPICAL SCORE IN CLINICAL MANAGEMENT OF PATIENTS WITH PT2 INVASIVE UROTHELIAL CARCINOMA

INTRODUCTION AND OBJECTIVE:The mapping of the genome through the TCGA collaborative project recently revealed major intrinsic molecular subtypes, Basal, Luminal, and Neural muscle-invasive urothelial carcinoma (UC), which have shown prognostic and predictive values. A standardized approach in daily practice, which is simple, fast, reproducible, and at low cost has not yet been identified. We provide to test the hypothesis that immuno-phenotypical score classification (Piescore) may discriminate Luminal from Basal from Neural UC, and to find an association of tumor Piescore with histological and clinical prognostic variables in a mono-institutional cohort of muscle-invasive (pT2) UC treated with trans-urethral resection and radical cystectomy (RC).METHODS:Primary endpoint is to stratify Luminal, Basal or Neural tumors according to a simple immuno-phenotypical score. Consecutive transurethral …