Effects Of Gut Microbial Metabolite Trimethylamine N-Oxide (Tmao) On Platelets And Endothelial Cells
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION(2020)
摘要
Thrombotic events result from different pathologies and are the underlying causes of severe diseases like stroke or myocardial infarction. Recent basic research now revealed a link between food uptake, food conversion and gut metabolism. Gut microbial production of trimethylamine N-oxide (TMAO) from dietary nutrients like choline, lecithin and L-carnitine was associated with the development of cardiovascular diseases. Within this review we give a systematic overview about the influence of TMAO on blood components like platelets and endothelial cells which both are involved as key players in thrombotic processes. In summary, a mechanistic correlation between the gut microbiome, TMAO and cardiovascular diseases becomes obvious and emphasizes to the significance of the intestinal microbiome.
更多查看译文
关键词
Microbiome, trimethylamin-N-oxide, platelets, endothelial cells, atherosclerosis
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要