Decreased HD-MIR2911 absorption in human subjects with the SIDT1 polymorphism fails to inhibit SARS-CoV-2 replication

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CAS Article Google Scholar Download references This work was supported by grants from the Chinese Science and Technology Major Project of China (2015ZX09102023-003), National Key Research and Development Plan (2018YFA0507100), National Basic Research Program of China (973 Program) (2014CB542300 and 2012CB517603), National Natural Science Foundation of China (81250044, 81602697, and 31741075), the Natural Science Foundation of Jiangsu Province (BE2016737), and the Fundamental Research Funds for the Central Universities (020814380130, 020814380133, 020814380137, and 020814380146). These authors contributed equally: Zhen Zhou, Yu Zhou, Xia-Ming Jiang, Yanbo Wang Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy, State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute of Life Sciences (NAILS), NJU Institute of AI Biomedicine and Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu 210023, China Zhen Zhou, Yu Zhou, Yanbo Wang, Xi Chen, Chen-Yu Zhang \u0026 Liang Li State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei 430071, China Xia-Ming Jiang, Gengfu Xiao \u0026 Lei-Ke Zhang Department of Critical Care Medicine and Nanjing infectious Disease Center, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210003, China Yongxiang Yi You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar L.L., L.Z, Y.Y., and C.Z. conceived and designed the experiments; Z.Z., Z.Y., X.J., Y.W. participated in multiple experiments; Z.Z., G.X., C.Z., L.L., X.C. analyzed the data. Z.Z., C.Z., L.L. wrote the manuscript. C.Z., Y.Y., L.Z., and L.L. provided the final approval of the manuscript. Correspondence to Chen-Yu Zhang or Yongxiang Yi or Lei-Ke Zhang or Liang Li. The authors declare that they have no conflict of interest. Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. Reprints and Permissions Zhou, Z., Zhou, Y., Jiang, X. et al. Decreased HD-MIR2911 absorption in human subjects with the SIDT1 polymorphism fails to inhibit SARS-CoV-2 replication. Cell Discov 6, 63 (2020). https://doi.org/10.1038/s41421-020-00206-5 Download citation Received: 01 June 2020 Accepted: 14 August 2020 Published: 11 September 2020 DOI: https://doi.org/10.1038/s41421-020-00206-5